Dual Actions of DPDPE on DAMGO Induced Antinociceptive Activity
نویسندگان
چکیده
منابع مشابه
The metabolic evidence of synergistic interaction between DAMGO and DPDPE on undifferentiated SH-SY5Y cells.
Recent studies have demonstrated the analgesic synergy between mu- and delta-opioid receptor, but evidence obtained at the cellular level is scanty. This work was designed to find the evidence of synergy between the actions of D-Ala2-Mephe4-glyol5 enkephalin (DAMGO) and D-Phe2, D-Phe5 enkephalin (DPDPE) on undifferentiated SH-SY5Y cells. Microphysiometer was used to detect the functional activi...
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Intracranial self-administration of mu- and delta-opioid agonists was demonstrated in male Long-Evans rats. Independent groups were allowed to lever-press for ventral tegmental area (VTA) microinfusions of morphine, the selective mu agonist [D-Ala2,N-Me-Phe4-Gly5-ol]-enkephalin (DAMGO), the selective delta-agonist [D-Pen2,D-Pen5]-enkephalin (DPDPE), or ineffective drug vehicle. Morphine, DAMGO,...
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Direct hyperalgesia induced by prostaglandin E, (PGE,) can be blocked by Nbut not 6or K-opioids. However, there is evidence that Kand &opioid receptors are located on sympathetic postganglionic neuron (SPGN) terminals, which mediate bradykinin (BK) hyperalgesia via SPGN-terminal-dependent production of PGE,. Therefore, we evaluated the antinociceptive effect of 6and K-opioids on BK hyperalgesia...
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15 صفحه اولDelta opioid receptor enhancement of mu opioid receptor-induced antinociception in spinal cord.
Although the mu selective agonist [D-Ala2-MePhe4-Gly-ol5]enkephalin (DAMGO) and the delta selective agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) are both antinociceptive when administered directly into the spinal cord of mice, 50% of antinociceptive dose (AD50) of DAMGO is about 2 orders of magnitude lower than the AD50 of DPDPE. In contrast, the two ligands show similar affinities for their respe...
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ژورنال
عنوان ژورنال: PAIN RESEARCH
سال: 1993
ISSN: 0915-8588,2187-4697
DOI: 10.11154/pain.8.99